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What is the mechanism of action of Tadalafil and what are the potential side effects?

Tadalafil belongs to the group of PDE-5 inhibitors and is primarily used to treat erectile dysfunction. Users should be aware of potential side effects when using this medication.
  • Tadalafil has the longest duration of action among drugs in its class, lasting up to 36 hours.
  • The onset of the effect typically occurs approximately 30 minutes after ingestion.
  • It can be used for both on-demand treatment and long-term therapy, depending on individual needs.
  • If you have any questions or require guidance regarding Tadalafil, you can seek advice through an online consultation at ApothekeGerman.

What is Tadalafil and how does it work?

Tadalafil is an active ingredient used as a sexual enhancer to treat erectile dysfunction. By inhibiting the enzyme PDE-5, it facilitates the occurrence of erections. Mechanism of action: In the case of erectile dysfunction, insufficient blood supply to the erectile tissue of the penis often occurs, resulting in the absence of a sustained erection. The premature breakdown of the enzyme phosphodiesterase-5 (PDE-5) and the subsequent breakdown of the messenger substance cGMP can contribute to this condition. Tadalafil works by inhibiting the premature breakdown of PDE-5, leading to increased cGMP levels. This allows for improved blood flow to the penis, facilitating a lasting erection. It’s important to note that Tadalafil does not increase libido.

Duration of action

Tadalafil has a longer half-life compared to other PDE-5 inhibitors. While the effect of sildenafil lasts for a maximum of six hours, Tadalafil can remain effective for up to 36 hours. It is typically taken approximately 30 minutes before planned sexual activity, regardless of food intake or moderate alcohol consumption. Alternatively, a daily low-dose regimen can be chosen for consistent therapy, enabling spontaneous sexual intercourse.

Possible side effects of Tadalafil:

As a PDE-5 inhibitor, Tadalafil can have various side effects, including gastrointestinal discomfort, headaches, dizziness, changes in blood pressure, and allergic skin reactions. Eye-related symptoms such as pain, irritation, and visual disturbances may also occur, requiring immediate medical attention. Rare but severe side effects can include strokes, heart attacks, sudden hearing loss, or sudden cardiac death. Due to these potential risks, it is crucial to use Tadalafil only under thorough medical guidance. Dosage and intake recommendations: The recommended single dose of Tadalafil ranges from 10 to 20 mg, to be taken at least 30 minutes before the desired effect with a glass of water. It is essential not to exceed the total prescribed dose within a day. For long-term ED consistency therapy, daily doses of 2.5 or 5 mg are common. Treatment of benign prostatic syndrome involves a daily dose of 5 mg, while pulmonary arterial hypertension is treated with a single daily dose of 40 mg.

Considerations and precautions

Patients with severe liver or kidney disorders should take a maximum of 10 mg of Tadalafil per day. It is contraindicated for individuals who have experienced a heart attack within the last three months or a stroke within the last six months. Consultation with a doctor is advised for those with other cardiovascular conditions or conditions causing painful prolonged erections (priapism). Tadalafil is not suitable for use by women. Interactions may occur with other medications, including HIV medication, antifungal agents, certain antibiotics, rifampicin, or specific anticonvulsants, potentially reducing or nullifying the effects of Tadalafil. Concurrent administration with certain medications, such as nitric oxide donors or antihypertensives, can cause a drop in blood pressure.

Long-term use of Tadalafil

In addition to on-demand use, Tadalafil can be used for consistent therapy. Daily low doses maintain a reduced level of PDE-5, facilitating spontaneous sexual activities. Tadalafil is well-suited for this approach due to its extended half-life, and studies have shown positive results for long-term therapy, particularly among diabetics who face challenges in treating erectile dysfunction.  
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